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[mhitesman]

Not sure if the quote below (source noted at bottom) is relevant to dogs (this for humans) regarding fluconazole or not, but since Comet is back on meds, I wanted to start up the research on meds again...since his sudden lameness sounds like a central nervous system attack (right??).  He was never on fluconazole, but I was wondering if I should broach the subject to the vet (who will find out on Monday that I have started Comet on itra again ....)  Note the 8.9 MONTHS.  I saw, on this same site for humans, that the average recommended treatment time for humans is 6 months.  The AMVA recommends 2 months according to my vet!!!  Comet was on for 4 months which appears to not have been long enough ....

Fluconazole (Diflucan)
Description The role of fluconazole therapy in blastomycosis is limited. In a small pilot study involving 23 patients, a successful outcome was noted in only 15 (65%) of cases. Better results were reported recently using higher dosages of fluconazole (400-800 mg/d). A successful outcome was noted for 34 (87%) of 39 patients treated for a mean duration of 8.9 mo. Although fluconazole demonstrates excellent CNS penetration, its role in the treatment of blastomycotic meningitis and cerebral abscesses is anecdotal.
Adult Dose 400-800 mg/d PO
Pediatric Dose Not established
Contraindications Documented hypersensitivity; coadministration with cisapride
Interactions Levels may increase with hydrochlorothiazides; fluconazole levels may decrease with long-term coadministration of rifampin; coadministration of fluconazole may decrease phenytoin clearance; may increase concentrations of theophylline, tolbutamide, glyburide, and glipizide; effects of anticoagulants may increase with fluconazole coadministration; increases in cyclosporine concentrations may occur when administered concurrently
Pregnancy C - Fetal risk revealed in studies in animals but not established or not studied in humans; may use if benefits outweigh risk to

fetushttp://www.emedicine.com/ped/topic254.htm